The expression and significance of adaptin-2 in mice cochlea / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 83-85, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-748808
ABSTRACT
OBJECTIVE@#To investigate the expression of adaptin-2(AP-2) in mice cochlea and to discuss the probable role in the endocytosis of hair cells.@*METHOD@#Laser scanning confocal microscopy and immune-fluroscence histochemistry were performed in this study.@*RESULT@#In mature mice cochlea, the immunoreactivity for AP-2 was found in the inner hair cells cytoplasm. This protein mainly expressed in the hair cells basal part and nearby the ribbon synapse.@*CONCLUSION@#AP-2 protein mainly expressed in the hair cells synaptic activity zone , which suggested that AP-2 could play an important role in the synaptic vesicle endocytosis. This finding built the foundation for the further research involved in the physiological and pathological role of AP-2.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Synapses
/
Cochlea
/
Microscopy, Confocal
/
Adaptor Protein Complex alpha Subunits
/
Hair Cells, Auditory
/
Hair Cells, Auditory, Inner
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2015
Type:
Article
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