Expression of cancer-testis antigen SCP-1 mRNA in human nasopharyngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 343-345, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-748823
ABSTRACT
OBJECTIVE@#To investigate the gene expression of Cancer-Testis Antigen SCP-1 in human nasopharyngeal carcinoma.@*METHOD@#The SCP-1 mRNA were examined in the tumor tissues of 28 nasopharyngeal carcinoma cases and control pharynx vasitis tissues of 40 non-cancer cases by reverse transcriptase polymerase chain reaction. A randomized sample of positive expression of SCP-1 mRNA was extracted for DNA sequencing to examine the reliability of results. The correlation of the expression of SCP-1 mRNA with clinical data was analyzed by statistical method.@*RESULT@#The expression frequency of SCP-1 mRNA was 14.3% (4/28) in nasopharyngeal carcinoma and zero (0/40) in control pharynx vasitis tissue of non-cancer cases (P 0.05).@*CONCLUSION@#SCP-1 mRNA is expressed in some nasopharyngeal carcinoma, suggesting that SCP-1 might be a new tumor target antigen of nasopharyngeal carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
RNA, Messenger
/
Carcinoma, Squamous Cell
/
Case-Control Studies
/
Nasopharyngeal Neoplasms
/
Allergy and Immunology
/
Genetics
/
Metabolism
/
Antigens, Neoplasm
Type of study:
Controlled clinical trial
/
Observational study
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2007
Type:
Article
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