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Expression and distribution of aquaporin 1 in laryngeal carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 269-272, 2007.
Article in Chinese | WPRIM | ID: wpr-748859
ABSTRACT
OBJECTIVE@#To detect expression level and distribution of aquaporin 1 (AQP1) in laryngeal carcinoma tissues and try to find out the significance about the mechanism of AQP1 in the invasion of laryngeal carcinoma.@*METHOD@#Twenty cases of laryngeal carcinoma tissues and 15 cases of normal tissues beside tumors were acquired immediately after surgery. The expression and distribution of aquaporin 1 in laryngeal carcinoma were examined by RT-PCR, western blot analysis and immunohistochemical technique.@*RESULT@#AQP1 expresses on the capillary endothelia of laryngeal mucous lamina propria and laryngeal mucous glands of normal tissues and mainly on the capillary endothelia cells, tumor cells and cancer nests of laryngeal carcinoma tissues. AQP1 mRNA and protein expression level in laryngeal tumor tissues is remarkably stronger than that in normal tissues beside tumors.@*CONCLUSION@#The expression of AQP1 was increased in laryngeal carcinoma tissues over normal laryngeal tissues. It suggests that the mechanism of AQP1 in laryngeal carcinoma etiopathogenesis needs to be studied.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Carcinoma, Squamous Cell / Case-Control Studies / Laryngeal Neoplasms / Aquaporin 1 / Metabolism / Neoplasm Staging Type of study: Observational study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pathology / Carcinoma, Squamous Cell / Case-Control Studies / Laryngeal Neoplasms / Aquaporin 1 / Metabolism / Neoplasm Staging Type of study: Observational study Limits: Adult / Aged / Female / Humans / Male Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2007 Type: Article