Expression of Heparansulfate Interacting Protein (HIP) in benign prostatic hyperplasia,prostate intraepithelial neoplasia and prostate cancer
Journal of Medical Research
;
: 98-104, 2008.
Article
in Vietnamese
| WPRIM
| ID: wpr-749
ABSTRACT
Background:
Heparansulfate Interacting Protein (HIP) is up-regulated in various human cancer cell lines at both transcript and protein levels. HIP expression is related to the differentiation status and cancer development.Objectives:
To determine HIP in benign prostatic hyperplasia, prostatic intraepithelial neoplasia and prostate cancer tissues. Materials andmethod:
Western blot method was used to determine HIP expression in 3 different types of prostate tissue, including 11 prostate cancer samples, 2 benign prostatic hyperplasia samples and 11 prostatic intraepithelial neoplasia samples. Results. HIP was particularly up-regulated in prostate cancer and prostatic intraepithelial neoplasia, indicating that up-regulation of HIP expression may be an early event in tumorgenesis.Conclusion:
The expression of HIP was different between cancer, prostatic intraepithelial neoplasia tissue and benign prostatic hyperplasia. HIP may serve as a prognostic marker for prostate carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatic Hyperplasia
/
Prostatic Neoplasms
Language:
Vietnamese
Journal:
Journal of Medical Research
Year:
2008
Type:
Article
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