Expression and clinical significance of hypoxia-inducible factor-1alpha and angiopoietin-2 in laryngeal squamous cell carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 489-492, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-749042
ABSTRACT
OBJECTIVE@#To investigate the expressions and clinical significance of Hypoxia-Inducible Factor-1alpha (HIF-1alpha) and angiopoietin-2 (Ang-2) proteins in laryngeal squamous cell carcinoma.@*METHOD@#Immunohistochemical technique was used to detect the expressions of HIF-1alpha and Ang-2 protein in 52 laryngeal squamous cell carcinoma and 10 normal tissues.@*RESULT@#The positive rates of HIF-1alpha and Ang-2 proteins were significantly higher in laryngeal squamous cell carcinoma than those in normal tissues (P 0.05). The level of Ang-2 expression was also correlated with TNM stage, lymph node metastasis and histological differentiation of laryngeal squamous cell carcinoma. But not related to the age and sex. There was positive correlations between both expressions of HIF-1alpha and Ang-2 proteins (r = 0. 333, P < 0.01).@*CONCLUSION@#High expressions of HIF-1alpha and Ang-2 proteins in laryngeal squamous cell carcinoma may play an important role in tumor growth, invasion and metastasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Carcinoma, Squamous Cell
/
Case-Control Studies
/
Laryngeal Neoplasms
/
Angiopoietin-2
/
Hypoxia-Inducible Factor 1, alpha Subunit
/
Lymphatic Metastasis
/
Metabolism
Type of study:
Observational study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2008
Type:
Article
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