Change of ACTH and cortisol in patients with obstructive sleep apnea hypopnea syndrome after the operation of uvulopalatopharyngoplasty / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 397-402, 2008.
Article
in Chinese
| WPRIM
| ID: wpr-749061
ABSTRACT
OBJECTIVE@#To explore the change of hypothalamus-pituitary-adrenal hormone in patients with Obstructive sleep apnea hypopnea syndrome (OSAHS) by observing the change of Corticotropin (ACTH) and cortisol after Uvulopalatopharyngoplasty (UPPP).@*METHOD@#OSAHS patients were monitored by polysomnography (PSG). The ACTH and cortisol levels in plasma were measured by radioimmunoassay before, during and after sleep in pre-operation and six months post-operation. Their correlation were analyzed.@*RESULT@#The cortisol concentration [ (170.4+/-56.5) microg/L, (252.2+/-62.3) microg/L, (276.9+/-70.4) microg/L, (2859.0+/-63.2) microg/L, (395.1+/-85.2) microg/L before, during and after sleep] in the before UPPP group were significantly higher than those of the after UPPP group [(133.5+/-24.8) microg/L, (99.9+/-9.2) microg/L, (103.8+/-13.2) microg/L, (146.2+/-22.5) microg/L, (199.6+/-20.9) microg/L before, during and after sleep, respectively, all P <0. 05]; but there was no difference in corticotropin(ACTH). The average blood oxygen concentration was negatively correlated with average awareness duration (r = -0.713).@*CONCLUSION@#There are abnormal change of HPA axis in OSAHS patients, and the feedback regulation is disordered. These abnormalities are related to sleep awareness and hypoxia during sleep.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Palate
/
Pharynx
/
Postoperative Period
/
General Surgery
/
Uvula
/
Blood
/
Hydrocortisone
/
Adrenocorticotropic Hormone
/
Sleep Apnea, Obstructive
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2008
Type:
Article
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