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Changes of serum aminotransferase in children with obstructive sleep apnea hypopnea syndrome / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery ; (24): 809-812, 2013.
Article in Chinese | WPRIM | ID: wpr-749243
ABSTRACT
OBJECTIVE@#Obstructive sleep apnea hypopnea syndrome (OSAHS) and non-alcoholic fatty liver disease (NAFLD) are both strongly associated with obesity. Whether OSAHS is an independent risk factor for liver injury or not is uncertain. To assess the hypothesis that OSAHS is associated with liver injury independent of obesity.@*METHOD@#One hundred and thirty children with OSAHS and 77 children with primary snoring(PS) were enrolled. Polysomnography was performed. Body mass index (BMI), liver function tests, serum lipids, fasting plasma glucose (FPG), and insulin (INS) were measured.@*RESULT@#Seventeen children of OSAHS had elevated serum aminotransferase levels,while only 2 children of non-OSAHS had elevated serum aminotransferase in healthy control group (chi2 = 5.18, P < 0.05; OR = 5.64 CI 1.27-24.97). Fifteen children of obese had elevated serum aminotransferase levels, while only 4 children had elevated serum aminotransferase in non-obese group (chi2 = 4.58, P < 0.05; (OR = 1.97 CI 1.06-3.67). Seventy cases of obese children, 15 cases of elevated aminotransferase levels (21.4%), namely fatty liver patients, of these children, 14 had OSAHS (93.3%). In contrast, OSAHS was present in only 67.3% of obese children without elevated aminotransferase.@*CONCLUSION@#OSAHS may be a risk factor for liver injury independent of obesity; Increased liver enzyme levels are frequently found in obese snoring children, particularly among those with OSAHS.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Snoring / Blood / Blood Glucose / Body Mass Index / Case-Control Studies / Risk Factors / Sleep Apnea, Obstructive / Fatty Liver / Transaminases / Insulin Type of study: Etiology study / Observational study / Risk factors Limits: Adolescent / Child / Female / Humans / Male Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2013 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Snoring / Blood / Blood Glucose / Body Mass Index / Case-Control Studies / Risk Factors / Sleep Apnea, Obstructive / Fatty Liver / Transaminases / Insulin Type of study: Etiology study / Observational study / Risk factors Limits: Adolescent / Child / Female / Humans / Male Language: Chinese Journal: Journal of Clinical Otorhinolaryngology Head and Neck Surgery Year: 2013 Type: Article