Study on laryngeal cancer related on polymorphism of the Arg399Gln of XRCC1 DNA repair gene in different nationalities in Xinjiang / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 948-954, 2013.
Article
in Chinese
| WPRIM
| ID: wpr-749256
ABSTRACT
OBJECTIVE@#To study genetic polymorphism of XRCC1 Arg399Gln and the laryngeal cancer risk.@*METHOD@#A case-control study was performed on 60 patients with laryngeal squamous cell carcinoma and 120 random healthy control group. The two groups were matched by sex and age. Multiplex SNaPshot technic was used to explore polymorphism of DNA repair gene XRCC1 Arg399Gln in distribution of patient with laryngeal squamous cell carcinoma and normal control.@*RESULT@#The frequency of XRCC1c. 399Arg/Gln+Gln/Gln genotypes in the case group was higher than that in the control group (P Gln might lead to a increased risk of laryngeal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Ethnicity
/
Case-Control Studies
/
China
/
Laryngeal Neoplasms
/
Epidemiology
/
Polymorphism, Single Nucleotide
/
DNA-Binding Proteins
/
DNA Repair
/
X-ray Repair Cross Complementing Protein 1
/
Genetics
Type of study:
Observational study
/
Risk factors
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2013
Type:
Article
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