Synergistic interactions of TRAIL and paclitaxel on the nasopharyngeal carcinoma cell lines in vitro / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 319-322, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-749405
ABSTRACT
OBJECTIVE@#To investigate the synergistic cytotoxicity of TRAIL and paclitaxel on nasopharyngeal cell lines CNE-1 and CNE-2.@*METHOD@#CCK-8 assays the growth inhibition rate of CNE-1 and CNE-2 which was treated with TRAIL or paclitaxel or combination of both. Flow cytometry tests the apoptosis rate of CNE-1 and CNE-2 which was treated with TRAIL or paclitaxel or combination of each other.@*RESULT@#In certain range of time and concentration,TRAIL and paclitaxel inhibited the growth of the cell lines of CNE-1 and CNE-2 in a time-dose dependent manner (P < 0.05). The rate of growth inhibition and apoptosis in TRAIL and paclitaxel combinative group was more significant than that in the TRAIL and paclitaxel singular group (P < 0.05).@*CONCLUSION@#TRAIL and paclitaxel had a synergistic killing effect on NPC cell lines and showed better affection than singular group, which provides a novel and prospective strategy for NPC chemotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Carcinoma
/
Nasopharyngeal Neoplasms
/
Paclitaxel
/
Apoptosis
/
Cell Line, Tumor
/
Receptors, TNF-Related Apoptosis-Inducing Ligand
/
Nasopharyngeal Carcinoma
Limits:
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS