Significance and expression of VEGF and its receptor in nasal inverted papillomas and the correlation with malignant phenotype / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 337-342, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-749431
ABSTRACT
OBJECTIVE@#To determine the expression of vascular endothelial growth factor (VEGF) and their receptor in nasal inverted papillomas (NIP) and to clarify the function of VEGF in the occurrence of NIPs and the correlation with malignant phenotype.@*METHOD@#VEGF and its receptor (flk-1), expression were examined by immunohistochemistry using LSAB method in sections of NIP from 48 patients and squamous carcinoma from 8 patients.@*RESULT@#All the epithelium together with the adjacent vascular and stroma,expressed increased positive staining of VEGF and flk-1 with the degree of atypical hyperplasia in epithelium. The VEGF/flk-1 expression in epithelium was significantly stronger in severe atypical hyperplasia than that in mild atypical hyperplasia, and same in mild atypical hyperplasia than in NIPs (P<0.01).@*CONCLUSION@#VEGF/flk-1 participate in the growth of NIPs. The enhanced VEGF/flk-1 in the epithelium may be identified as one of the parameters in judging malignant transformation of NIPs.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Carcinoma, Squamous Cell
/
Nose Neoplasms
/
Papilloma, Inverted
/
Vascular Endothelial Growth Factor Receptor-2
/
Vascular Endothelial Growth Factor A
/
Genetics
/
Metabolism
Type of study:
Prognostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS