Aggressive fibromatosis of the head and neck (A report of two cases and literature review) / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 107-109, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-749479
ABSTRACT
OBJECTIVE@#To evaluate the clinic manifestation, pathologic behavior, therapy and prognosis of rare aggressive fibromatosis in the head and neck.@*METHOD@#Two cases of aggressive fibromatosis were analyzed and relevant literatures were reviewed.@*RESULT@#Aggressive fibromatosis was characterized as infiltrative, locally aggressive and tended to recur after surgical resection. Pathology showed fibroblastic monoclonal proliferation. Fibromatosis was composed of well-differentiated fibroblasts and myofibroblasts, lacking cytological features of malignancy and scanty or absent mitotic activity. Complete surgical excision of aggressive fibromatosis was considered to be the only effective method of cure by most authorities. Chemotherapy and radiotherapy can be used together with surgery in recurrence or unsatisfactory surgical margin. In our study, one patient recurred after the first operation, and after another operation, the patient did not recur after 6 months follow up, and the other one did not recur after 6 months follow up.@*CONCLUSION@#The diagnosis of aggressive fibromatosis depended on pathological examination. Radical removal was an important way to reduce recurrence rate. Radiation therapy and chemotherapy can be used as adjuvant therapy in patients with recurrent or unresectable or inoperable disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
General Surgery
/
Fibromatosis, Aggressive
/
Diagnosis
/
Head and Neck Neoplasms
Type of study:
Diagnostic study
/
Prognostic study
Limits:
Adolescent
/
Female
/
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2012
Type:
Article
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