Relationship between Testin expression and clinicopathological characteristics in nasopharyngeal carcinoma patients / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 310-313, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-749702
ABSTRACT
OBJECTIVE@#To investigate the expression of Testin gene, and analyze its possible relationship with the clinicopathological features of human nasopharyngeal carcinoma.@*METHOD@#The expression of Testin in nasopharyngeal carcinoma tissues were detected by immunohistochemistry methods, semi-quantitative reverse transcription polymerase chain reaction and Western blot. The correlations of Testin to clinicopathologic features of nasopharyngeal carcinoma were analyzed.@*RESULT@#The positive expression rate of Testin in NPC biopsy tissue was 37.8% (17/ 45), while it was 88.9% (40/45) in the normal tissue; The expression of Testin mRNA was significantly lower than that in the normal tissue (P 0.05); but it had significant correlation with lympho node metastasis, distant metastasis and differentiation degree.@*CONCLUSION@#The decreased expression of Testin gene may play an importmant role in the development of nasopharyngeal carcinoma. And thus Testin gene might be a novel candidate of tumor-suppressor. It may be an objective marker for prognostic factor and malignant level for nasopharyngeal carcinoma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
RNA, Messenger
/
Immunohistochemistry
/
Carcinoma
/
Nasopharyngeal Neoplasms
/
Genes, Tumor Suppressor
/
Cytoskeletal Proteins
/
LIM Domain Proteins
/
Nasopharyngeal Carcinoma
/
Metabolism
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2016
Type:
Article
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