Expression and clinical pathological implications of carbonic anhydrase 9 and P glycoprotein in laryngeal squamous cell carcinoma / 临床耳鼻咽喉头颈外科杂志
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
;
(24): 42-44, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-749731
ABSTRACT
OBJECTIVE@#To identify the difference of CA IX and P-gp expression level between laryngeal squamous cell carcinoma (LSCC) and benign tissues, evaluate the relationship of these two proteins in LSCC, and their correlation with clinical and pathological features.@*METHOD@#Immunohistochemical detection of CA IX and P-gp were performed in 47 cases of LSCC and 20 cases of vocal cord polyps.@*RESULT@#Overexpression of CA IX and P-gp both in LSCC and in vocal cord polyp (P < 0.05) were confirmed, with a correlation between the two proteins in LSCC (r = 0.324, P < 0.05). The expression of CA IX was related to clinical staging and lymph node metastasis in LSCC (P < 0.05). While P-gp was related to clinical staging and histological grading in LSCC (P < 0.05).@*CONCLUSION@#The overexpression of CA IX and P-gp may play a role in LSCC progression.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Polyps
/
Vocal Cords
/
Carcinoma, Squamous Cell
/
Laryngeal Neoplasms
/
Carbonic Anhydrases
/
ATP Binding Cassette Transporter, Subfamily B
/
Neoplasm Grading
/
Carbonic Anhydrase IX
/
Lymphatic Metastasis
Type of study:
Prognostic study
Limits:
Humans
Language:
Chinese
Journal:
Journal of Clinical Otorhinolaryngology Head and Neck Surgery
Year:
2016
Type:
Article
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