Clinical characteristics and long-term outcomes related to sputum eosinophilia in Korean asthmatics
Asia Pacific Allergy
;
(4): 16-24, 2011.
Article
in English
| WPRIM
| ID: wpr-749859
ABSTRACT
BACKGROUND:
Bronchial asthma is usually associated with high sputum eosinophil levels. However, recent reports have suggested the importance of noneosinophilic asthma (NEA) as a distinct phenotype of asthma.OBJECTIVE:
The aim of this study was to evaluate clinical significance of sputum eosinophilia and long-term treatment outcomes related to sputum eosinophilia in Korean asthmatics.METHODS:
A total of 201 steroid-naive asthmatics who had undergone induced sputum analysis at baseline were selected from the Cohort for Reality and Evolution of Adult Asthma study population. Clinical evaluation, spirometry, a skin-prick test, a methacholine bronchial provocation test, and sputum eosinophil analysis were performed initially, and patients received the treatment recommended by the Global Initiative for Asthma. Lung function was evaluated every 6 months, and 53 patients completed 24 months of regular follow-up visits. Sputum eosinophilia was defined as a sputum eosinophil count of >3%.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phenotype
/
Asthma
/
Spirometry
/
Sputum
/
Bronchial Provocation Tests
/
Forced Expiratory Volume
/
Cohort Studies
/
Follow-Up Studies
/
Methacholine Chloride
/
Eosinophilia
Type of study:
Etiology study
/
Incidence study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
Language:
English
Journal:
Asia Pacific Allergy
Year:
2011
Type:
Article
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