Interferon-alpha inhibits airway eosinophila and hyperresponsiveness in an animal asthma model
Asia Pacific Allergy
;
(4): 256-263, 2012.
Article
in English
| WPRIM
| ID: wpr-749918
ABSTRACT
BACKGROUND:
Asthma is characterized by a chronic inflammatory process involving high numbers of inflammatory cells and mediators which have multiple inflammatory effects on the airway. Interferon (IFN)-alpha, which is used widely for treating chronic hepatitis C, is reported to have an effect on patients with Churg-Strauss syndrome. Therefore, it may also be suitable for patients with severe asthma.OBJECTIVE:
We studied the effect of IFN-alpha on airway eosinophilia in a guinea pig model of asthma and the expression of adhesion molecules on human eosinophils and vascular endothelial cells.METHODS:
After antigen challenge, airway hyperresponsiveness and airway eosinophilia were measured in a guinea pig asthma model with or without airway IFN-alpha administration. Expression of adhesion molecules on eosinophils and cultured human umbilical vein endothelial cells (HUVECs) was also evaluated with or without IFN-alpha.RESULTS:
IFN-alpha inhibited eosinophil recruitment into the tracheal wall and improved airway hyperresponsiveness in sensitized guinea pigs. IFN-alpha also significantly suppressed IL-1 beta-induced intercellular adhesion molecule-1 (ICAM-1) expression on HUVECs. However, IFN-alpha did not suppress platelet-activating factor-induced macrophage antigen-1 expression on human eosinophils. IFN-alpha significantly inhibited eosinophil adhesion to IL-1 beta-induced HUVECs and migration through IL-1 beta induced HUVECs.CONCLUSION:
The findings suggest that the modulation of ICAM-1 in lung with pre-existing inflammation following treatment with IFN-alpha may be a novel and selective treatment for control of chronic airway inflammation and hyperresponsiveness associated with asthma.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Asthma
/
Churg-Strauss Syndrome
/
Interferons
/
Interleukin-1
/
Interferon-alpha
/
Intercellular Adhesion Molecule-1
/
Hepatitis C, Chronic
/
Endothelial Cells
/
Eosinophilia
/
Eosinophils
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
English
Journal:
Asia Pacific Allergy
Year:
2012
Type:
Article
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