Penicillin allergy evaluation: experience from a drug allergy clinic in an Arabian Gulf Country, Kuwait
Asia Pacific Allergy
;
(4): 106-112, 2014.
Article
in English
| WPRIM
| ID: wpr-749983
ABSTRACT
BACKGROUND:
Hypersensitivity to penicillin has been studied worldwide, but data regarding patterns of sensitization in Arabian Gulf countries are scarce.OBJECTIVE:
To describe the patterns of penicillin hypersensitivity during a 6-year study in Kuwait in terms of demographics, type of the culprit drug, in vivo and in vitro allergy testing.METHODS:
One hundred and twenty-four patients referred to the drug allergy clinic for penicillin allergy were fully evaluated by skin prick and intradermal testing. Drug provocation test was done on patients with negative results.RESULTS:
A total of 124 patients were evaluated for penicillin allergy. Mean age was 37.8 (standard deviation, 12.7) years, range from 8 to 74 years. Thirty-nine male (31.5%) and 85 female patients (68.5%) were included. Diagnosis of penicillin allergy was confirmed in 46 patients (37.1%). Among the 44 confirmed allergic patients by skin evaluation we had 15 (34.1%) positive skin prick test, and 29 (65.9%) positive intradermal testing. Among patients with positive skin testing, 47.7% were positive to major determinant benzylpenicilloyl poly-L-lysine, 20.4% to minor determinant mixture, 50.0% to penicillin G and 40.9% to ampicillin; 13.6% of patients were positive to amoxicillin by skin prick test. One patient had a positive radioallergosorbent test and one had a positive challenge test.CONCLUSION:
Penicillin allergy is a common problem with an incidence of about one third in our study subjects.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Penicillin G
/
Penicillins
/
Skin
/
In Vitro Techniques
/
Intradermal Tests
/
Radioallergosorbent Test
/
Skin Tests
/
Demography
/
Incidence
/
Diagnosis
Type of study:
Diagnostic study
/
Incidence study
/
Prognostic study
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Asia Pacific Allergy
Year:
2014
Type:
Article
Similar
MEDLINE
...
LILACS
LIS