Gynecomastia induced by H1-antihistamine (ebastine) in a patient with idiopathic anaphylaxis
Asia Pacific Allergy
;
(4): 187-190, 2015.
Article
in English
| WPRIM
| ID: wpr-750027
ABSTRACT
H1-antihistamine is generally a well-tolerated and safe drug. However, in resemblance with all other drugs, H1-antihistamines can also prompt adverse drug reactions (ADRs). We recently encountered the very unusual ADR of H1-antihistamine-induced gynecomastia. A 21-year-old man with idiopathic anaphylaxis was treated with ebastine (Ebastel), a second-generation H1-antihistamine, for the prevention of anaphylaxis. Three months later, the patient remained well without anaphylaxis, but had newly developed gynecomastia. Because anaphylaxis recurred after the cessation of H1-antihistamine, the preventive medication was changed to omalizumab. A few months later, his gynecomastia had entirely disappeared. Physicians should be aware of this exceptional ADR of H1-antihistamine.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drug-Related Side Effects and Adverse Reactions
/
Omalizumab
/
Gynecomastia
/
Histamine H1 Antagonists
/
Anaphylaxis
Limits:
Humans
/
Male
Language:
English
Journal:
Asia Pacific Allergy
Year:
2015
Type:
Article
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