Ibuprofen induced Stevens-Johnson syndrome
Asia Pacific Allergy
;
(4): 70-73, 2016.
Article
in English
| WPRIM
| ID: wpr-750045
ABSTRACT
Despite the fact that any drug can be an impending cause of hypersensitivity reactions, Ibuprofen, an over-the-counter drug used extensively as an analgesic and antipyretic in Asia, is considered to be relatively safe. But herein we report a rare extremely 'rapid onset' occurrence of a severe case of Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) in a 22-year-old male, induced by 3 doses of 400 mg of Ibuprofen taken at 8-hour interval for eye pain, probably the first case report of rapid onset of TEN by nonsteroidal antiinflammatory drugs in Nepal. SJS and TEN are idiosyncratic, delayed hypersensitivity inflammatory adverse drug reactions that are severe adverse cutaneous drug reactions which predominantly involve the skin and mucous membranes and are linked with high morbidity and mortality. Nevertheless, removal of ibuprofen and its metabolites with plasma exchange and treatment with antibiotics and intravenous corticosteroids along with supportive therapy improved the course of the disorder. This rare case report addresses the fact that severe hypersensitivity reactions can occur with Ibuprofen, which can be potentially dangerous and life threatening. It is thus important for the clinicians to be alert to such severe hypersensitivity reactions even with drugs which are deemed to be probably safe.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Plasma Exchange
/
Asia
/
Skin
/
Ibuprofen
/
Mortality
/
Stevens-Johnson Syndrome
/
Adrenal Cortex Hormones
/
Drug-Related Side Effects and Adverse Reactions
/
Eye Pain
/
Hypersensitivity
Type of study:
Prognostic study
Limits:
Humans
/
Male
Country/Region as subject:
Asia
Language:
English
Journal:
Asia Pacific Allergy
Year:
2016
Type:
Article
Similar
MEDLINE
...
LILACS
LIS