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Human ex vivo and in vitro disease models to study food allergy
Asia Pacific Allergy ; (4): e4-2019.
Article in English | WPRIM | ID: wpr-750170
ABSTRACT
Food allergy is a growing global public health concern. As treatment strategies are currently limited to allergen avoidance and emergency interventions, there is an increasing demand for appropriate models of food allergy for the development of new therapeutics. Many models of food allergy rely heavily on the use of animals, and while useful, many are unable to accurately reflect the human system. In order to bridge the gap between in vivo animal models and clinical trials with human patients, human models of food allergy are of great importance. This review will summarize the commonly used human ex vivo and in vitro models of food allergy and highlight their advantages and limitations regarding how accurately they represent the human in vivo system. We will cover biopsy-based systems, precision cut organ slices, and coculture systems as well as organoids and organ-on-a-chip. The availability of appropriate experimental models will allow us to move forward in the field of food allergy research, to search for effective treatment options and to further explore the cause and progression of this disorder.
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biological Phenomena / In Vitro Techniques / Allergens / Organoids / Public Health / Coculture Techniques / Models, Animal / Emergencies / Food Hypersensitivity / Anaphylaxis Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Asia Pacific Allergy Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Biological Phenomena / In Vitro Techniques / Allergens / Organoids / Public Health / Coculture Techniques / Models, Animal / Emergencies / Food Hypersensitivity / Anaphylaxis Type of study: Prognostic study Limits: Animals / Humans Language: English Journal: Asia Pacific Allergy Year: 2019 Type: Article