Allergy to carminic acid: in vitro evidence of involvement of protein-binding hapten
Asia Pacific Allergy
;
(4): e2-2019.
Article
in English
| WPRIM
| ID: wpr-750172
ABSTRACT
We previously described a rare case of anaphylaxis presumably induced by carminic acid in cochineal dye used as a food additive. In this study, highly pure carminic acid was added to an albumin-containing buffer at various concentrations, followed by serial dilution. Varying the mixing ratio of carminic acid and albumin affected the extent of histamine release from passively sensitized basophils. Similar basophil histamine release occurred with carminic acid-globulin solutions. These results provide experimental evidence indicating that basophil activation is dependent on hapten (carminic acid) and carrier (protein) interaction.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Basophils
/
In Vitro Techniques
/
Carmine
/
Food Additives
/
Histamine Release
/
Hypersensitivity
/
Anaphylaxis
Language:
English
Journal:
Asia Pacific Allergy
Year:
2019
Type:
Article
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