A Brief Review on ACE I/D Gene Polymorphism and Blood Pressure Response to Exercise Training
Malaysian Journal of Medicine and Health Sciences
;
: 179-189, 2018.
Article
in English
| WPRIM
| ID: wpr-750661
ABSTRACT
@#Exercise has been suggested as the best and the most affordable way for managing blood pressure. The insertion/ deletion of angiotensin I-converting enzyme (ACE) I/D gene polymorphism had been reported to be linked with several diseases such as hypertension and diabetic nephropathy. Several studies showed that blood pressure response to exercise training for health management also vary among individuals with different genotypes of ACE I/D gene polymorphism. A study of 9 months of endurance exercise training at 75 to 85 % of VO2max showed that the decrease of resting blood pressure in I allele carriers wass greater than D allele carriers. In contrast, other study discovered that adult women with D allele had greater reduction in resting blood pressure than those with I allele, following a 12-week combined aerobic and resistance exercise training. Despite the inconsistencies of some findings, it has remained unknown if the ACE I/D gene polymorphism would also influence blood pressure response to isometric handgrip training that had been found to be superior to the dynamic resistance exercise training in controlling and preventing high blood pressure. Thus, this article was to review the literature on ACE I/D gene polymorphism and blood pressure response to exercise training that could serve as the basis for future research to identify individuals who will lower resting blood pressure the most with exercise training program for health management.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Blood Pressure
Type of study:
Prognostic study
Language:
English
Journal:
Malaysian Journal of Medicine and Health Sciences
Year:
2018
Type:
Article
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