The Pattern of Failure after Definitive Radiotherapy for Squamous Cell Carcinoma of the Lung / 대한치료방사선과학회지

ABSTRACT

From Feb. 1985 to Feb. 1988, 76 patients with squamous cell carcinoma of the lung treated at the Department of Therapeutic Radiology in Kyungpook National University Hospital were available for the analysis of this study. All patients received radiation of 4000c0y-6600c0y with curative aim. The overall rate of complete response was 25.0% and partial response was 52.6%. The complete and partial regression of tumor was 14.3% in patients treated with dose below 5000 cGy and 84.1% in the group treated with dose above 5000 cGy (p<0.01). The complete response was seen only in the group of patients received radiation at least 6000 cGy. The patterns of failure were as follows. The rate of initial intrathoracic recurrence was 52.6% in patients with complete response. The overall rate of failure was 67.8%. Distant metastasis was found in 47.4% of patients. Bone, contralateral lung, and brain were common metastatic sites in decreasing order. All of the distant metastases and 80% of local recurrences were found within the first year after treatment.