Clinical features of diabetic patients with bacterial liver abscess and different levels of glycosylated hemoglobin / 临床肝胆病杂志

ABSTRACT

@#ObjectiveTo investigate the clinical features of diabetic patients with bacterial liver abscess and different levels of glycosylated hemoglobin (HbAlc). MethodsA total of 118 adult diabetic patients with bacterial liver abscess who were admitted to our hospital from December 2014 to December 2018 were enrolled, and according to the level of HbAlc, they were divided into well-controlled group with 32 patients, fairly-controlled group with 31 patients, and poorly-controlled group with 55 patients. The three groups were compared in terms of general data, clinical manifestations, laboratory results, complications, and pathogen test results. A one-way analysis of variance was used for comparison of continuous data between multiple groups, and the least significant difference t-test was used for further comparison between two groups; the chi-square test or the Fisher’s exact test was used for comparison of categorical data between groups. ResultsThere were significant differences in mean age and length of hospital stay between the three groups (F=2.933 and 3.310, both P＜0.05). Compared with the other two groups, the poorly-controlled group had a significantly younger mean age of onset (P=0.016) and a significantly longer length of hospital stay (P=0.044). Hypertension was the most common underlying disease in diabetic patients with liver abscess, followed by biliary tract diseases and cerebral infarction, and there was a significant difference in cerebral infarction between the three groups (χ2=6.135, P=0037). Compared with the well-controlled group, the poorly-controlled group had significantly fewer and less typical signs of abdominal tenderness (χ2=6.178, P=0.046), and compared with the other two groups, the poorly-controlled group tended to have a significant increase in C-reactive protein (χ2=5.985, P=0.049) and were more likely to develop sepsis (χ2=6.247, P=0.044). ConclusionFor diabetic patients with bacterial liver abscess, the patients with a poorly controlled HbAlc level often have a young age of onset, a long length of hospital stay, and atypical clinical signs and are likely to develop sepsis, which may lead to insufficient attention in clinical practice, delay diagnosis and treatment, and even endanger life, and therefore, such patients should be taken seriously in clinical practice.