Progress of detection techniques of Philadelphia chromosome鄄like acute lymphoblastic leukemia / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 254-256, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-751391
ABSTRACT
Philadelphia chromosome_like acute lymphoblastic leukemia (Ph_like ALL) characterized by a high rate of relapse and poor outcome of chemotherapy and prognosis, also known as BCR_ABL1_like ALL, is a kind of B_ALL subtypes, a pattern of gene expression profiling similar to that of BCR_ABL1 ALL positive but lacking BCR_ABL1 fusion gene. With the better understanding of gene expression profiling, the World Health Organization (WHO) (2016) has regarded Ph_like ALL as an independent subtype of B_ALL. The diagnosis highly depends on the laboratory techniques, and a wide range of diagnostic methods can be applied in clinic, which may bring a big challenge for the clinicians. This paper reviews the various laboratory techniques of Ph_like ALL and subtype group analysis, to provide a basis for target therapy and to improve the prognosis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Type of study:
Diagnostic study
Language:
Chinese
Journal:
Journal of Leukemia & Lymphoma
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS