Progress of OX40 and its ligand in lymphoma immunotherapy / 白血病·淋巴瘤
Journal of Leukemia & Lymphoma
;
(12): 371-375, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-751409
ABSTRACT
OX40 is a member of the tumor necrosis factor receptor (TNFR) superfamily. In the immune response of the body, OX40 and the OX40 ligand (OX40/OX40L) on the antigen-presenting cell membrane are important co-stimulatory molecules, which can promote the proliferation of T cells. And OX40 also has the dual role of activating and enhancing the T cell immune response. OX40/OX40L is an important target for tumor immunotherapy, and clinical studies of several OX40 agonists are currently underway. This article reviews the immunoregulatory mechanisms of OX40/OX40L and its research progress in lymphoma immunotherapy.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Journal of Leukemia & Lymphoma
Year:
2019
Type:
Article
Similar
MEDLINE
...
LILACS
LIS