Progress on the function of forkhead box C2 / 国际儿科学杂志

ABSTRACT

FOXC2,a transcription factor of the forkhead/winged-helix family,possesses a classical forkhead domain,which is required for embryonic and prenatal development.FOXC2 acts as a crucial modulator during tumor cell proliferation,metastasis,angiogenesis,lymphangiogenesis,renal disease and metabolism,but very little is known about the precise underlying mechanisms.Therefore,an in-depth study of FOXC2 is helpful to further understand the pathogenesis and developmental mechanism of FOXC2-related diseases.The purpose of this review is to summarize the current understanding of FOXC2 and its function.