Expression and prognostic values of circ_0009910 in gastric cancer / 国际外科学杂志

ABSTRACT

Objective To study the expression and significance of circ_0009910 in gastric cancer,and evaluate its correlation with clinicopathological characteristics and prognostic value.Methods From Feb.2010 to Nov.2014,there were 129 gastric cancer patients in Beijing Haidian Hospital.One hundred and twenty-nine cases of tumor tissues and 129 paracancerous non-tumor tissues were collected from gastric cancer patients,intraoperatively.The expression of circ_0009910 was detected by qRT-PCR experiment.Then the correlations of circ_0009910 with major clinicopathological characteristics were analyzed.The Kaplan-Meier method was used to analyze overall survival of patients.A Cox proportional hazards regression analysis was used for multivariate analyses of prognostic values.Results The expression level of circ_0009910 in tumor tissues of patients was significantly higher than that in paracancerous non-tumor tissues (P ＜0.01).The expression level of circ_0009910 in patients was significantly associated with clinical stage (P =0.032),distant metastasis (P =0.018) and differentiation (P =0.007),respectively.There was no obvious correlation of the expression level of circ_0009910 with age,gender,Lauren's classification,tumor diameter (P ＞0.05).And the expression level of circ_0009910 was higher in patients with advanced cancer (stage Ⅲ/Ⅳ),distant metastasis and poor differentiation.Survival rate of patients in positive group was significantly lower than negative group (P =0.001 5),with 5-year survival rate were about 29.5％ and 53.2％,respectively.circ_0009910 (P =0.006),distant metastasis (P =0.009) and differentiation (P =0.035) were independent risk factors of overall survival of patients,respectively.Conclusions The expression level of circ_0009910 in tumor tissues of gastric cancer patients was significantly higher than that in paracancerous non-tumor tissues,which was significantly correlated with clinical stage,distant metastasis and differentiation.Survival rate was lower in patients with higher expression level of circ_0009910.circ_0009910 was an independent risk factors of overall survival of patients.