Molecular alterations in precancerous lesions of esophageal squamous cell carcinoma / 国际肿瘤学杂志

ABSTRACT

Esophageal squamous cell carcinoma (ESCC)is one of the most predominant malignancies worldwide. ESCC develops gradually from the precancerous lesions. The researches about biomarkers mainly concentrate in the nucleic acid and protein,including cytogenetic abnormalities,amplifications,deletions,muta-tions,breakage and fusions of genomic DNA,expression changes of mRNA,microRNA (miRNA)and long non-coding RNA (lncRNA)in RNA level,and expression level,subcellular localization,and post-translational modi-fications of proteins. Studies on the molecular alterations in precancerous lesions and early cancer of the esopha-gus will contribute to the exploration of biomarkers for early diagnosis and intervention targets for this disease.