Effect of Huoxue-Xiaozheng decoction on ovarian function and mifepristone on the patients with uterine leiomyoma after operation / 国际中医中药杂志

ABSTRACT

Objective To investigate the effect of Huoxue-Xiaozheng decoction on ovarian function and mifepristone of in patients with uterine leiomyoma after operation.Methods A total of 90 patients with uterine leiomyoma after operation were divided into the observation group and control group according to random number table method,with 45 cases in each group.The control group were treated with mifepristone,and the observation group with Huoxue-Xiaozheng decoction on the basis of the control group.The serum sex hormone (FSH,LH,E2,P and T),cell factor (TGF-β3,IL-22,FSH,LH,E2,P and T) and the uterine volume between two groups after treatment were compared,and the recurrence rate of uterine leiomyoma was compared between the two groups after treatment.Results After treatment,the serum sex hormone FSH (17.11 ± 4.01 μg/L vs.20.16 ± 5.21 μg/L,t=3.112),LH (16.78 ± 3.34 μg/L vs.19.52 ± 4.32 μg/L,t=3.366),E2 (156.60 ± 46.32 pmol/L vs.220.31 ± 50.11 pmol/L,t=6.263),P (8.37 ± 2.50 μg/L vs.15.23 ± 2.45 μg/L,t=13.1467),T (0.23 ± 0.05 ng/ml vs.0.31± 0.06 ng/ml,t=6.8712),cell factor TGF-β3 (22.08 ± 4.34 μg/L vs.28.10 ± 5.02 μg/L,t=6.086) of the observation group were significantly lower than those of the control group (P＜0.01).After treatment,the uterine volume (85.42 ± 19.35 cm3 vs.97.37 ± 20.45 cm3,t=2.847) of the observation group was significantly lower than that of the control group (P＜0.01).After 2 years of follow-up,the uterine fibroids overall recurrence rate of the observation group was 13.3％ (6/45),while the control group was 31.1％ (14/45),.The difference between two groups,was statistically significant (x2=4.114,P=0.043).Conclusions The Huoxue-Xiaozheng decoction combined with mifepristone can effectively inhibit the secretion of ovarian hormones and decrease the expression of TGF-β3,IL-22,FSH,LH,E2,P and T in patients with uterine leiomyoma.