Clinical study of Huayu-Tongbi decoction combined with sarpogrelate in the treatment of senile diabetes mellitus complicated with arteriosclerosis obliterans of lower extremities / 国际中医中药杂志

ABSTRACT

Objective To evaluate the effect of Huayu-Tongbi decoction combined with sarpogrelate in the treatment of senile diabetes mellitus complicated with arteriosclerosis obliterans (ASO) of lower extremities. Methods A total of 105 ASO patients who met the inclusion criteria were divided into control group (52 cases) and observation group (53 cases) by random number table method. The control group was treated with oral sarpogrelate. The observation group was treated with Huayu-Tongbi decoction on the basis of the control group. Both groups were treated for 2 months. The level of FPG, HbA1c, TC, HDL-C and LDL-C were detected by automatic biochemical analyzer. The arteriosclerosis index (AI), ankle brachial index (ABI) and intima-media thickness (IMT) were calculated. The internal diameter of posterior tibial artery and dorsal pedal artery, peak velocity and blood flow were measured by ultrasound detector before and after treatment in two groups. The clinical effect was evaluated. Results The total effective rate was 94.3% (50/53) in the observation group and 76.9% (40/52) in the control group. There was a significant difference between the two groups (χ2=6.502, P=0.011). After treatment, the level of FPG, HbA1c, TC and LDL-C in the observation group was significantly lower than those in the control group (t were 5.201, 6.716, 5.878 and 10.293, respectively, all Ps<0.01). internal diameter of posterior tibial artery and dorsal pedal artery, peak velocity and blood flow in the observation group were significantly larger than those in the control group (t were 4.295, 6.639, 8.310, 5.045, 5.393 and 9.672, respectively, all Ps<0.01). After treatment, the AI (4.23 ± 0.65 vs. 4.81 ± 0.83, t=3.991), IMT (0.95 ± 0.10 mm vs. 1.11 ± 0.13 mm, t=4.829) in the observation group were significantly lower than those in the control group ( P<0.01), while the ABI (1.10 ± 0.19 vs. 0.93 ± 0.17, t=7.077) was significantly higher than those in the control group (P<0.01). Conclusions The Huayu-Tongbi decoction combined with sarpogrelate can regulate the disorder of glucose and lipid metabolism in elderly diabetic patients with ASO, improve the blood circulation of posterior tibial artery and dorsal pedal artery, in order to improve the clinical effect.