Study on the Relationship between Thyroid Function and Gastrointestinal Motility and Motilinlevels / 昆明医科大学学报

ABSTRACT

Objective To analysis the relationship between thyroid function with gastrointestinal motility and plasma motilin levels, and to provide the basis for clinical application.Me thods We selected 30 cases of patients with hyperthyroidism, 30 cases of hyperthyroidism group and hypothyroidism as hypothyroidism group, and 30 healthy volunteers as control group who were treated in our hospital from January 2013 to January 2016 in;The radioimmunoassay was used to test serum motilin levels, isotope single photon emission computed tomography was used to detected the gastric liquid technology half time, esophageal transit time.Re s ults The esophagus passage time of the subjects in the hypothyroidism group was significantly higher than that of the hyperthyroidism group and the control group, and the difference was statistically significant (P＜0.05);The level of motilin in serum of hyperthyroidism group was significantly higher than that of control group (P＜0.05), and the level of motilin in serum of hypothyroidism group was significantly lower than that of control group (P＜0.05);Hyperthyroidism was positively correlated with motilin level (r = 0.542, P＜0.05), and negatively correlated with the time of passage of the esophagus and gastric emptying time (r =-0.126 and r =-0.481, P＜0.05);Hypothyroidism was negatively correlated with motilin level (r =-0.617, P＜0.05), and positively correlated with esophageal transit time and gastric emptying time (r = 0.627 and r = 0.416, P ＜0.05).Conclus ions Hyperthyroidism can lead to the increase of gastrointestinal function and motilin level. Hypothyroidism can lead to the decrease of gastrointestinal function and motilin level.