A Study on Expression of Histone Deacetylase-2 in Humantongue Squamous Cell Carcinomas / 昆明医科大学学报

ABSTRACT

Objective To study the expression of HDAC2 and the correlations with pathological parameters in human tongue squamous cell carcinoma, and to analyze the correlation between them and patients' clinical indicators and survival status.Methods A total of 96 cases of humantongue squamous cell carcinoma (SCC), 24 dysplasia (ED), 13 normal mucosa (NOM) were involved in this study. The expression of HDAC2 was evaluated by ICH. Kaplan-Meier was used to research cumulative surviving of SCC patients.Result Among 96 cases of SCC samples, 86 cases showed positive expression (89.6％), The differences between the overexpression of HDAC2 and the pathological grading, lymph node metastasis, the patient's age and gender were insignificant (all P＞0.05). However, the differences of TNM presented statistically significant (χ2 = 18.600, P＜0.001). 14 out of 24 ED (58.3％) were positive expression of HDAC2, there were 7 cases (53.8％) of positive expression samples in NOM. The expression of HDAC2 in SCCs was significantly higher than that in ED and NOM (χ2= 118.407, P＜0.00). There was no significant difference of cumulative surviving between the positive and negative SCC patients (P = 0.184). However cumulative surviving of patients with lymph node metastasis was significantly shorter than those with no metastasis (P＜0.000).Conclusions The expression of HDAC2 in SCC was significantly higher than that in ED and NOM, the TNM stage of patients presented the significant difference of expression of HDAC2, patients with lymph node metastasis were significantly shorter than those with no metastasis, and demonstration can be used as a reliable reference molecule for the evaluating prognosis of SCC.