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Pathological changes of lung, pancreas and kidney in abdominal compartment syndrome / 中华内分泌外科杂志
Chinese Journal of Endocrine Surgery ; (6): 202-207, 2019.
Article in Chinese | WPRIM | ID: wpr-751984
ABSTRACT
Objective To explore the pathological changes of lung,pancreas and kidney in abdominal compartment syndrome by making an animal model of abdominal hypertension.Methods 20 New Zealand rabbits were divided into 3 groups,4 in the control group,8 in the experiment group 1,and 8 in group 2.The control group were not injected with pressure water capsule,the pressure was 0 mmHg(0 Kpa),and the time limit was 48 hours.The pressure and increased volume of abdominal pressure was recorded each time of injection of 50 ml saline in group 1 and group 2.The abdominal pressure-volume curve was plotted.Then the pressure of the experimental group was adjusted to 22 mmHg(2.96 Kpa),and the time limit of experimental group 1 was 24 hours,the group 2 was 48 hours.The experimental animals were killed at the time of observation,the whole lung,pancreas and kidney were completed and fixed with 10% Formaldehyde solution for 24 hours,and the routine paraffin was embedded,sliced,stained with HE,and observed under the biological optical microscope.Results During the experiment,4 of the control group survived,1 died in the experimental group 1,and 2 died in group 2.There was a positive correlation between abdominal pressure and increasing volume of abdominal cavity in the experimental group of abdominal high pressure liquid animal model.The function equationY=0.1486X-119.0000 (R2=0.827 4,P=0.004 5).Pathological changes of lungs in three groups of experimental animalscontrol groupterminal bronchioles and a large number of alveoli in normal lungs,interstitial small vessel dilatation.The group 1alveolar epithelial hyperplasia,alveolar septum size,alveolar lumen fusion,alveolar interstitial bleeding,dark brown matter deposition,intravascular thrombus,and computerized recanalization.In the group 2,the alveoli were dilated obviously,some alveolar cavities were fused,the alveolar septum was not one,and a large number of red cells and cellulosic exudates were found in the terminal fine bronchioles,including dark brown matter deposition.Pathological changes of pancreas in the three groupscontrol groupacinusacinar cell consists of a layer of vertebral acinar cells,the nucleus was round,close to the base of the cell,and the nucleolus was obvious;the basal cytoplasm was basophilic because of the rich in rough endoplasmic reticulum and ribosome.The group 1pancreatic acinar degeneration,large number of inflammatory cells infiltrating in the pancreatic tissue,lymphatic sinus dilation,lymph nodes filled with lymph,lymphatic edema,paranantral lymph nodes,lymphatic sinus dilatation,sinus endothelial cell proliferation and lymphoid hyperplasia.In the group 2,the pancreatic acini were markedly degenerated,blood vessels were dilated and congested in the interstitium,and the lymphatic vessels in the pancreatic tissue expanded and contained large amounts of lymph.Pathological changes of kidney in three groups of experimental animalscontrol groupglomeruli and blood vessels were basically normal,and renal tubules were slightly dilated.The group 1mild segmental hyperplasia of glomerular mesangial cells,mild enlargement of mesangial matrix,dilatation of renal tubules,internal protein tube type,granulosa like degeneration of renal tubular epithelial cells and dilatation and congestion of endoplasmic blood vessels.Experimental group 2glomerular segmental hyperplasia,renal tubular epithelial cell edema,renal tubule dilatation,canalicular type in the lumen,small vessels of the renal interstitium dilated and hyperemia.Conclusion Lung,pancreas and kidney have obvious secondary damage at the development of abdominal compartment syndrome and aggravates with the extension of time.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Endocrine Surgery Year: 2019 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Endocrine Surgery Year: 2019 Type: Article