Meta-Analysis of Curative Effects of Traditional Chinese Herbal Decoction on Breast Carcinoma Patients in doxorubicin-induced cardiotoxicity / 世界科学技术-中医药现代化

ABSTRACT

Objective: To analyze the curative effects of traditional Chinese herbal decoction on breast carcinoma patients in doxorubicin-induced cardiotoxicity by meta-analysis to provide evidences for doctors in treating breast carcinoma patients who were in doxorubicin-induced cardiotoxicity by traditional Chinese herbal decoction.Method: Published papers about the curative effects of traditional Chinese herbal decoction on doxorubicin-induced cardiotoxicity in breast carcinoma patients in clinical random control experiment were collected. To analyze the prescription rules and do metaanalysis in the eligible ones by the software RevMan5.2. Evaluate clinical effects of traditional Chinese medicine in treating breast carcinoma patients who were in doxorubicin-induced cardiotoxicity.Results: Ten references and 648 cases in total meeting eligibility criteria were included. Compared with pure anthracycline-based chemotherapy drugs, the breast carcinoma patients who received Anthracycline-based chemo therapy drugs with traditional Chinese medicine, their ECG changes less, their difference was statistically significant (OR=0.23, 95％ CI (0.16, 0.16), P ＜0.00001) . They had better cardiac function. the difference was statistically significant (OR=0.18, 95％ CI (0.09, 0.09), P ＜0.00001) . Their left ventricular systolic function improved. Their difference was statistically significant (MD = 3.82, 95％CI (0.29, 0.29), P=0.03 ＜ 0.05) . The myocardial enzyme spectrum, cardiac troponin I and myocardial troponin T were improved. Conclusion: To some extent, decoction of Chinese herbal medicine has effects on breast carcinoma patients with myocardial anthracycline-based drugs damage.