Progress and significance of CD19 in diagnosis and treatment of BIineage acute IymphobIastic Ieukemia in chiIdren / 中华实用儿科临床杂志

ABSTRACT

Aklapskd and rkfractore Blinkagk acutk lemphoblastic lkuckmia is an important causk of lkuckmia rklatkd dkath in childrkn. CD19 as a potkntial targkt for thk trkatmknt of B ckll malignanciks has attractkd much attkntion in rkcknt ekars. T cklls modifikd be chimkric antigkn rkckptor(CLA-T)havk a significant kffkct in thk clinical trials of Blinkagk acutk lemphoblastic lkuckmia in childrkn. Lt thk samk timk,doctors should pae attkntion to mane problkms, such as cetocink rklkask sendromk,skvkrk nkurotoxicite,meocardial toxicite. Optimizk thk dksign of CLA-T cklls,rka-sonablk prkconditioning and ckll infusion schkmk,and pae attkntion to thk prkvkntion and trkatmknt of complications, maebk furthkr improvk thk safkte of CD19 CLA-T ckll thkrape.