Clinical significance of serum gastrin,C _ reactive protein and D _ dimer in Henoch _ Sch?nlein purpura children with abdominal symptoms / 中华实用儿科临床杂志

ABSTRACT

Objective To investigate the clinical significance of serum gastrin _17,C _ reactive protein ( CRP)and D_dimer(D_D)levels in early diagnosis and severity evaluation of Henoch_Sch?lein purpura(HSP) children with abdominal symptoms. Methods Retrospective analysis was performed in 120 children with initial HSP admitted to the Department of Pediatrics,the First Affiliated Hospital of Anhui medical University from December 2016 to December 2017,among them,there were 70 cases with abdominal symptoms,and 50 patients without abdominal symptoms. And 20 healthy children who underwent health consultation at the First Affiliated Hospital of Anhui medical University were selected as a healthy control group. Serum gastrin_17,CRP and D_D levels in acute phase in the HSP children were detected,and the correlation between these parameters and purpura symptom scores was analyzed. Together with gastroscope,the severity of HSP with abdominal symptoms was evaluated. Results (1)Serum gastrin_17 level in HSP children with abdominal symptoms were obviously lower than that of the other of type HSP group and the healthy control group[(3. 12 ± 1. 64)pmol/L υs.(6. 85 ± 1. 28)pmol/L and(7. 15 ± 1. 03)pmol/L],and the differences were statistically significant(all P<0. 001);the levels were decreased most significantly in HSP children with early gastrointestinal symptoms[(1. 77 ± 0. 50)pmol/L υs.(4. 01 ± 1. 51)pmol/L],and the difference was sta_tistically significant(P<0. 001);the pathological changes under gastroscope were obvious in HSP children with early gastrointestinal symptoms(χ2 =8. 095 2,P<0. 05).(2)Serum CRP and D_D levels in the HSP children with abdo_minal symptoms were striking higher than those in the healthy control group[(18. 39 ± 4. 48)mg/L υs.(3. 95 ± 1. 65) mg/L;(2. 53 ± 1. 17)mg/L υs.(0. 59 ± 0. 41)mg/L],and the differences were statistically significant( all P <0. 001 ),which were both increased most significantly in the HSP children with early gastrointestinal symptoms [(19. 98 ± 5. 45)mg/L υs.(17. 33 ± 3. 37)mg/L;(3. 48 ± 0. 96)mg/L υs.(1. 89 ± 0. 80)mg/L],and the diffe_rences were statistically significant(all P<0. 05).(3)Serum gastrin_17 level was negatively correlated with purpura symptom scores(r= _0. 907,P<0. 01);serum CRP and D_D levels were both positively correlated with purpura symptom scores(r=0. 974,0. 928,all P<0. 01). Conclusions Serum gastrin_17,CRP and D_D levels in acute phase can be used as serological markers for early diagnosis of HSP children with abdominal symptoms,especially in HSP children with early gastrointestinal symptoms.