Relationshipbetweenwhitematterintegrityandperipheralinterleukin10inschizophrenia / 实用放射学杂志

ABSTRACT

Objective Toexploretherelationshipbetweenthemicrostructuralintegrityofwhitematter(WM)andperipheralinterleukin10 (IL-10)inschizophrenia.Methods Diffusion MRIdataandvenousbloodsampleswereacquiredfrom47schizophreniapatients(SZ) and49healthycontrols (HC).Tract-basedspatialstatisticswasconductedtoexaminethedifferencesinFAandradialdiffusivity (RD)betweentwogroups.QuantitativechemiluminescenceassaywasperformedtomeasureperipheralIL-10levels.Regressionanalysiswas conductedtoinvestigatetherelationshipbetweenperipheralIL-10levelsanddiffusion measures (FAandRD).Results Compared withHC,therewerewidespreadreductionsinFAandincreaseinRDinSZ.Additionally,comparedwith HC,peripheralIL-10levels werehigherinSZ.PeripheralIL-10wasnegativelycorrelatedwithFAintherightposteriorthalamicradiationandleftinferiorfronto-occipitalfasciculusamongthepatients(β=-0.51,P=0.01andβ=-0.47,P=0.02,respectively)butnotcontrols(β=-0.01,P=0.95 andβ=-00.03,P=09.8,respectively).Andthecorrelationcoefficientsofthetwogroupsweredifferent(z=25.0,P=00.1andz=23.7,P=00.2, respectively).Conclusion TheperipheralIL-10maycontributetothedisruptionsofmicrostructuralWMintegrityinschizophrenia, supportingthenotionforanimportantroleofinflammationinthepathogenesisofschizophrenia.