Toll-like receptor signaling pathway as a potential therapeutic target for colorectal cancer / 实用肿瘤学杂志
Practical Oncology Journal
;
(6): 188-192, 2019.
Article
in Chinese
| WPRIM
| ID: wpr-752837
ABSTRACT
Toll-like receptors(TLRs) signaling pathways are involved in the activation of innate and adaptive immune re-sponse and play an important role in the development of colorectal cancer. Deregulation of TLRs signaling pathway can lead to epitheli-al hemorrhage,chronic inflammation and the development of colorectal cancer. There is now lots of evidence that targeting this pathway will benefit the treatment of colorectal cancer,such as BCG,monophosphatidyl A,and iquimod,etc. ,which are now in clinical use. This article reviews current different function of TLRs in tumor development and their application in the treatment of colorectal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Language:
Chinese
Journal:
Practical Oncology Journal
Year:
2019
Type:
Article
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