Effect of ibudilast-microinjected into nucleus accumbens on appendix pain threshold in morphine-addicted rats / 实用肿瘤学杂志
Practical Oncology Journal
; (6): 211-214, 2019.
Article
in Zh
| WPRIM
| ID: wpr-752841
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WPRO
ABSTRACT
Objective The aim of this study was to investigate the effect of microinjection ibudilast on the appendix pain threshold in nucleus accumbens(NAC)of morphine-addicted rats. Methods Normal rats and morphine-addicted rats were injec-ted with ibudilast(5 μg/2 μL)or saline(2 μL)into NAC through glass microelectrode. The tail-flick period(TFL)was used as an in-dicator to observe the thermal pain threshold before and after ibuilast injection. Results After injected ibudilast 5 μg into the NAC of normal rats and morphine-added rats,the TFL was prolonged compared with that before injection,and the TFL prolongation of mor-phine-addicted rats was more significant than that of normal rats. There was no significant change in TFL after 2 μL of saline was in-jected into the NAC of normal rats and morphine-addicted rats. Conclusion Microinjection of ibudilast into NAC of normal rats and morphine-added rats can cause analgesic effect,and the analgesic effect of morphine-addicted rats is more significant.
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WPRIM
Language:
Zh
Journal:
Practical Oncology Journal
Year:
2019
Type:
Article