Progress in long-chain non-coding RNA in osteosarcoma / 实用肿瘤学杂志

ABSTRACT

Osteosarcoma(OS)is a malignant tumor that occurs mostly in children and adolescents with a poor prognosis. The 5-year survival rate and the survival rate of patients with lung metastasis or distant metastasis are still unsatisfactory. Currently,the treatment of osteosarcoma is still unsatisfactory under the bottleneck period. Long-chain non-coding RNA(LncRNA)is a non-pro-tein-encoding RNA molecule involved in a variety of processes including gene expression,chromatin remodeling,post-transcription-al processing and transcription. LncRNAs are abnormally expressed in human cancers and they are involved in tumor development, progression and metastasis. This article reviews the research progress of long-chain non-coding RNA in osteosarcoma,which is in-tended to provide further research for osteosarcoma and propose new diagnosis and treatment strategies.