Advances progress of N6-methyladenine and cancer / 实用肿瘤学杂志

ABSTRACT

N6-methyladenine(m6 A),a major RNA methylation modification,affects the development and progression of hu-man cancer through a variety of mechanisms. The m6 A modification also affects multiple aspects of RNA metabolism,ranging from RNA processing,nuclear export,RNA translation to decay. In this review,the basic concepts of m6 A methylation,regulation of m6 A methyltransferase complex and m6 A demethylases in several cancers and some m6 A performed the biological function of the modifica-tion as m6 A-binding proteins are introduced. In addition,the dual role of m6 A methylation and its potential in clinical application are summarized in this review.