Mitochondrial function injury mechanism in septic cardiomyopathy / 中国小儿急救医学

ABSTRACT

Septic cardiomyopathy is a common complication in severe sepsis and septic shock,mito‐chondrial function injury is one of the main aspects of its pathogenesis. The heart is a continuous power or‐gan,needs a lot of ATP to maintain normal systolic and diastolic function. Mitochondrial as the main ATP producing organelles,accounts for about one third of the myocardial volume,which being damaged will be harmful to the myocardial energy supply and cardiac function. This paper introduced the latest research pro‐gress of mitochondrial damage in septic cardiomyopathy,including mitochondrial NO production increase and oxidative stress,Ca2+ overload and mitochondrial membrane permeability increase,mitochondrial uncoupling and mitochondrial homeostasis,also discussed the potential treatments.