Progress and prospects of biomarkers for liver injury in critically ill patients / 中国小儿急救医学

ABSTRACT

Liver injury is an independent risk factor for worse prognosis of patients with critically ill. The criteria for diagnosis of liver injury are based on the levels of alanine aminotransferase( ALT ≥ 2 fold the upper limit of normality)or total bilirubin(TBIL≥68 μmol/L). All these classic indicators have limita-tion to early identify liver injury. Recently,accumulated evidences indicated that novel potential biomarkers for predicting liver injury are worth more attention due to quick response to liver injury up to 0. 5-2 h. Here, we summarized these potential biomarkers including serum total bile acids,bile acids profiling,regulator of iron metabolism(transferrtin,ferritin and hepcidin),enzymes involved in mitochondria function(GLDH and MDH),key proteins for ornithine circulation pathway ( Arg Ⅰ,OCT and ASS),hepatocytes-derived cyto-kines(CK18,HMGB1 and miR122)and immunologic regulator(MIF).