Your browser doesn't support javascript.
loading
A study on the association between vascular endothelial growth factor A polymorphisms and necrotizing enterocolitis / 中国新生儿科杂志
Chinese Journal of Neonatology ; (6): 264-268, 2019.
Article in Chinese | WPRIM | ID: wpr-753024
ABSTRACT
Objective To study the relationship between single nucleotide polymorphisms (SNPs) of vascular endothelial growth factor A (VEGFA) gene and neonatal necrotizing enterocolitis (NEC).Method From August 2014 to December 2016,preterm infants with a ≥ Ⅱ stage (Modified Bell staging criteria) of NEC admitted to our hospitals were assigned as NEC group.Preterm infants without NEC with similar gestational age and body weight during the same period were assigned as the control group.SNPs of VEGFA including rs1005230,rs833067,rs3025010,rs3025035,rs3025036,rs10434,and rs6905288 were analyzed using SEQUENOM MassARRAY platform and multiplex allele-specific PCR.The concentration of VEGFA in the plasma of the two groups was examined using enzyme-linked immunosorbent assay (ELISA).Result A total of 110 infants were reviewed,including 30 infants in NEC group and 80 infants in the control group.The results showed a significant association of the minor allele frequency (MAF) for T in rs1005230 and C in rs833067 with NEC.The frequencies of C/T (OR=4.810,95%CI 1.742~13.278) and C/T-T/T (OR=4.892,95%CI 1.801~13.246) genotypes in rs1005230,and frequencies of T/C (OR=4.373,95%CI 1.578~12.129) and T/C-C/C (OR=4.000,95%CI 1.484~10.828) genotypes in rs833067 were significantly higher in NEC group than the control group (P<0.05).Infants with MAF in rs1005230 and rs833067 had significantly lower plasma level of VEGFA than infants without MAF (P<0.01).Conclusion The SNPs of rs1005230 and rs833067 may be associated with lower level of VEGFA in plasma and higher risk for NEC.

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Neonatology Year: 2019 Type: Article

Similar

MEDLINE

...
LILACS

LIS

Full text: Available Index: WPRIM (Western Pacific) Language: Chinese Journal: Chinese Journal of Neonatology Year: 2019 Type: Article