A study on the relationship between meconium-stained amniotic fluid, chorioamnionitis and the infections of the mother and the infant / 中国新生儿科杂志

ABSTRACT

Objective To study the influences of meconium-stained amniotic fluid (MSAF) and chorioamnionitis (CA) on maternal and infant infection.Method From July to December 2014,full-term single birth newborns with MSAF born in our hospital were assigned into the MSAF group.According to the pathological characteristics of the placenta,they were further assigned into CA group and non-CA group.The healthy single birth full-term infants without MSAF were assigned into the control group.The influences of MSAF and CA on maternal and infant infection were analyzed.Result A total of 178 MASF cases were enrolled,including 57 cases with CA and 121 cases without CA.42 infants were in the control group.The incidence of CA with MSAF (32.0％,57/178) was significantly higher than the control group (4.8％,2/42) (P＜0.05).The white blood cell counts on the first day of the CA group and non-CA group were (29.4±8.9)x 109/Land (22.8±4.8)x 109/L,respectively.36.8％ of the CA group had increased CRP within 3 days after birth,while 15.7％ in the non-CA group.The incidence of neonatal infection were 49.1％(28/57) in the CA group,and 20.7％(25/121) in the non-CA group.The incidence of meconium aspiration syndrome was 28.1％(16/57)in the CA group,and 8.3％(10/121) in the nou-CA group.The differences between the two groups were statistically significant (P＜0.05).The proportion of neutrophils of the mother was (80.3±7.3)％ in the CA group,and (76.4±7.6)％ in the non-CA group.22.8％(13/57) of the mothers in the CA group had fever before and after delivery,and 9.9％(12/121) in the non-CA group.The incidence of uterine infection was 8.8％(5/57) in the CA group and 0％(0/121) in the non-CA group.The postpartum hemorrhage rate was 24.6％(14/57) in the CA group,and 3.3％(4/121) in the non-CA group.The differences were statistically significant (P＜0.05).Conclusion The incidence of CA in MSAF neonates is higher,resulting increased incidences of neonatal infection,maternal fever,and uterine infection.