Influence of ticagrelor combined PCI on myocardial perfusion ,serum levels of PAF and PAC‐1 in AMI patients／ / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of ticagrelor combined percutaneous coronary intervention (PCI) on myo‐cardial perfusion ,serum levels of platelet activating factor (PAF) and activated platelet membrane glycoprotein Ⅱb／Ⅲa complex (PAC‐1) in patients with acute myocardial infarction (AMI ).Methods:A total of 120 AMI patients undergoing emergency PCI were selected , randomly and equally divided into clopidogrel combined aspirin group (control group) and ticagrelor combined aspirin group (T+ A group).Perfusion indexes ,cardiac function indexes and serum levels of PAF and PAC‐1 were measured and compared between two groups on 24h and six months after PCI ,and incidence of adverse events within six‐month was recorded .Results:After PCI ,there was no significant difference in TIMI grade 3 blood flow rate between two groups , P＝0.488. Compared with control group on six months after PCI ,there were significant rise in cardiac index [ (2.61 ± 1.31) L·min－1 ·m－2 vs.(3. 12 ± 1.37) L ·min－1 ·m－2 ] ,stroke volume [ (60.99 ± 5.13) ml vs.(71. 24 ± 5. 94) ml] and left ventricular ejection fraction [ (45.31 ± 6. 73 )% vs.(72.64 ± 7.29 )%] , and significant reductions in left ventricular end‐systolic dimension [ (59.41 ± 4. 12) mm vs.(53.12 ± 3.45) mm] ,serum levels of PAF [ (10. 31 ± 1. 69) μg／L vs .(8.26 ± 1.38) μg／L] and PAC‐1 [ (37.57 ± 5.74)% vs.(32.14 ± 4.93)%] in T+A group , P＜0. 05 or ＜0.01. During six‐month follow‐up ,no patient died in either group ,and incidence rate of adverse events in T+A group was significantly low‐er than that of control group (1. 67% vs.11.67%, P＝0. 028 ).Conclusion:Ticagrelor combined PCI can signifi‐cantly improve cardiac function and reduce peripheral blood levels of PAF and PAC‐1 with good safety in AMI pa‐tients .It′s worth clinical extension and application .