Therapeutic effect of domestic olmesartan medoxomil on early and middle essential hypertension and its influence on blood pressure variability／ / 心血管康复医学杂志

ABSTRACT

Objective :To study therapeutic effect of domestic olmesartan medoxomil on early and middle essential hy‐pertension (EH) and its influence on blood pressure variability (BPV).Methods :A total of 148 EH patients treated in our hospital were selected ,randomly and equally divided into domestic olmesartan medoxomil group (received do‐mestic olmesartan medoxomil treatment ) and Japan olmesartan medoxomil group (received olmesartan medoxomil made in Japan) ,and both groups were continuously treated for eight weeks .BPV indexes ,serum levels of 25－hy‐droxyl vitamin D [25 (OH) D] and homocysteine (Hcy) before and after treatment ,and therapeutic effect and in‐cidence of adverse reactions were observed and compared between two groups .Results :Compared with before treat‐ment ,after treatment ,there were significant reductions in BPV indexes (except nighttime SBP standard deviation ) and serum Hcy level [domestic olmesartan medoxomil group :(23.45 ± 2.48) μmol／L vs .(9.89 ± 1.39) μmol／L ,Ja‐pan olmesartan medoxomil group :(23.48 ± 1.50) μmol／L vs.(9. 83 ± 1.36) μmol／L] ,and significant rise in serum 25 (OH) D level [domestic olmesartan medoxomil group : (294. 89 ± 30.16) ng／L vs .(332. 27 ± 33. 76) ng／L ,Ja‐pan olmesartan medoxomil group :(295.73 ± 30.11) ng／L vs.(329. 71 ± 33. 68 ) ng／L ] in two groups , P＝ 0. 001 all ;there were no significant difference in BPV indexes ,serum levels of 25 (OH) D and Hcy ,total effective rate and incidence rate of adverse reactions after treatment between two groups , P＞ 0. 05 all.Conclusion : Domestic olmesartan medoxomil can significantly reduce BPV indexes with significant therapeutic effect and low incidence rate of adverse reactions in early and middle EH patients ,and it＇s no significant difference compared with olmesartan me‐doxomil made in Japan .It is worth application in clinic .