Therapeutic effect of Rhodiola grandiflora combined alprostadil on acute coronary syndrome and its in‐fluence on blood lipid levels／ / 心血管康复医学杂志

ABSTRACT

Objective:To study therapeutic effect of Rhodiola grandiflora combined alprostadil on acute coronary syn‐drome (ACS) and its influence on blood lipid levels .Methods: A total of 104 ACS patients ,who were treated in our hospital from Jul 2016 to Sep 2017 ,were selected ,randomly and equally divided into alprostadil group (received al‐prostadil injection based on routine treatment ) and combined treatment group (received Rhodiola grandiflora injec‐tion based on alprostadil group ) ,both groups were treated for two weeks .LVEDd ,LVEF ,levels of blood lipidTC ,TG ,HDL‐C ,LDL‐C ,serum high sensitive C reactive protein (hsCRP ) ,interleukin 6 (IL‐6) and monocyte chemoattractant protein‐1 (MCP‐1) before and after treatment ,total effective rate and incidence of adverse reac‐tions were observed and compared between two groups .Results: After two‐week treatment ,total effective rate of combined treatment group was significantly higher than that of alprostadil group (94.23% vs .78. 85%) , P＝0.022. Compared with before treatment ,after two‐week treatment ,there were significant reductions in LVEDd , levels of TC ,TG ,LDL‐C ,serum hsCRP ,IL‐6 and MCP‐1 ,and significant rise in LVEF and HDL‐C level in two groups , P＜0.05 or ＜0. 01. Compared with alprostadil group after two‐week treatment ,there were significant re‐ductions in LVEDd [ (58.07 ± 6. 14) mm vs.(55.12 ± 5. 06) mm] ,levels of TC [ (5.63 ± 0.94) mmol／L vs.(4. 75 ± 0.81) mmol／L] , TG [ (2. 78 ± 0.54) mmol／L vs.(2. 16 ± 0.47) mmol／L] , LDL‐C [ (3. 28 ± 0.57) mmol／L vs.(2.56 ± 0. 42) mmol／L] ,serum hsCRP [ (6.27 ± 1. 14) mg／L vs .(5. 39 ± 0. 96) mg／L] , IL‐6 [ (7.85 ± 1. 47) ng／L vs .(6. 82 ± 1. 30) ng／L] and MCP‐1 [ (113.74 ± 19.62) ng／L vs.(94.36 ± 16.58) ng／L] ,and significant rise in LVEF [(45.74 ± 8.48)% vs.(50.78 ± 8.34)%] and HDL‐Clevel [(2.36 ± 0. 52) mmol／L vs.(2. 93 ± 0. 57) mmol／L] in combined treatment group , P＜0.01 all.During treatment ,there was no significant difference in inci‐dence rate of adverse reactions between two groups , P＝0. 539. Conclusion:Rhodiola grandiflora combined alpros‐tadil possesses significant therapeutic effect on ACS .It can significantly improve cardiac function ,regulate blood lipid metabolism and reduce inflammation with low incidence of adverse reactions ,which is worth extending .