Influence of benidipine on blood pressure ,left ventricular hypertrophy ,UACR and baPWV in patients with morning hypertension / 心血管康复医学杂志

ABSTRACT

Objective:To explore influence of benidipine on blood pressure ,left ventricular hypertrophy (LVH) ,u—rine microalbuminuria／creatinine ratio (UACR ) and brachial—ankle pulse wave velocity (baPWV ) in patients with morning hypertension (MH).Methods: A total of 142 patients with essential hypertension treated in our department were randomly and equally divided into benidipine group and amlodipine group .The 24h ambulatory blood pressure (24hABP) before and two months after treatment ,ultrasonography ,urine microalbumin (UMA ) and creatinine (Ucr) and baPWV before and six months after treatment were measured in two groups ,and UACR was calculated . Results: Compared with before treatment , there were significant reduction in blood pressure in two groups after treatment ( P＝0.001 all) ,but there were no significant difference in blood pressure between two groups after treat—ment , P＞0. 05 all .Compared with amlodipine group after treatment ,there were significant rise in total effective rates of MH (56.06% vs .74.24%) and daytime blood pressure (62.12% vs.78.79%) in benidipine group , P＜0.05 both .Compared with before treatment , after treatment , there was significant reduction in UACR in two groups ( P＝0. 001 both) ,but there were no significant difference in UCG indexes and baPWV , P＞0.05 all.Com—pared with amlodipine group after treatment ,there was significant reduction in UACR [ (18.25 ± 1.53) μg／mg vs. (16.54 ± 1.42) μg／mg , P＝0.001] in benidipine group ,there were no significant difference in UCG indexes and baPWV between two groups ,P＞0.05 all.Conclusion: Both amlodipine and benidipine can effectively control blood pressure ;and benidipine possesses more significant therapeutic effect on total effective rates and UACR .