Therapeutic effect of butylphthalide on acute cerebral infarction and its influence on neurological func— tion and quality of life / 心血管康复医学杂志

ABSTRACT

Objective:To assess therapeutic effect of butylphthalide injection on acute cerebral infarction (ACI ) and its influence on neurological function and quality of life (QOL).Methods: A total of 106 ACI patients were enrolled from our hospital ,randomly and equally divided into routine treatment group and butylphthalide group (received bu—tylphthalide injection based on routine treatment ).After 14d treatment ,clinical therapeutic effect was assessed in two groups ;neurological function indexes were compared between two groups before and after treatment .Cognitive function and QOL were compared between two groups before and during follow—up .Results: Total effective rate of butylphthalide group was significantly higher than that of routine treatment group (88.68% vs.67.92%, P＝0.010).Compared with routine treatment group after 14d treatment ,there was significant reduction in score of U—nited States National Institutes of Health Stroke Score [NIHSS ,(9.47 ± 4. 24) scores vs .(6. 12 ± 3.81) scores] ,and significant rise in score of activity of daily living scale [Barthel index ,(45. 27 ± 6.78 ) scores vs .(63.19 ± 7.13 ) scores] in butylphthalide group , P＝0.001 both .Compared with routine treatment group during follow—up ,there were significant rise in scores of mini—mental state examination [MMSE ,(23.74 ± 4.82) scores vs.(27.56 ± 4.91) scores] ,Montreal Cognitive Assessment [MoCA , (24.07 ± 4. 98 ) scores vs .(27.96 ± 5.07 ) scores] and physical functioning ,social functioning ,mental health and general health dimension of the medical outcomes study 36—item short—form heath survey (SF—36) in butylphthalide group , P＝0. 001 all.Conclusion: Butylphthalide injection can significantly improve therapeutic effect ,neurological function ,cognitive function and quality of life in patients with acute cerebral infarction .